Tyk2-IN-5
Modify Date: 2024-01-10 14:15:57
Tyk2-IN-5 structure
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Common Name | Tyk2-IN-5 | ||
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| CAS Number | 1797432-62-2 | Molecular Weight | 434.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H19FN8O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tyk2-IN-5Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model[1]. |
| Name | Tyk2-IN-5 |
|---|
| Description | Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model[1]. |
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| Related Catalog | |
| Target |
Tyk2 JH2:0.086 nM (Ki) IFNα:25 nM (IC50) |
| References |
| Molecular Formula | C21H19FN8O2 |
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| Molecular Weight | 434.43 |