864374-00-5
864374-00-5 structure
- Name: TP0427736 HCl
- Chemical Name: TP0427736
- CAS Number: 864374-00-5
- Molecular Formula: C14H10N4S2
- Molecular Weight: 298.39
- Catalog: Research Areas Cancer
- Create Date: 2019-06-16 13:50:42
- Modify Date: 2025-08-25 03:26:10
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TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1].
| Name | TP0427736 |
|---|---|
| Synonyms |
6-[4-(4-Methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole
Benzothiazole, 6-[4-(4-methyl-2-thiazolyl)-1H-imidazol-5-yl]- |
| Description | TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 634.7±65.0 °C at 760 mmHg |
| Molecular Formula | C14H10N4S2 |
| Molecular Weight | 298.39 |
| Flash Point | 333.8±24.7 °C |
| Exact Mass | 298.034698 |
| LogP | 3.37 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.740 |
| Storage condition | Store at -20°C |
| Water Solubility | DMSO ：≥50mg/mL |
| Hazard Codes | N |
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