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  • DC Chemicals Limited
  • China
  • Product Name: CM-675
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1872466-47-1

1872466-47-1 structure
1872466-47-1 structure
  • Name: CM-675
  • Chemical Name: CM-675
  • CAS Number: 1872466-47-1
  • Molecular Formula: C31H32N6O3
  • Molecular Weight: 536.62
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
  • Create Date: 2019-06-30 10:26:15
  • Modify Date: 2024-01-08 18:08:26
  • CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease[1].

Name CM-675
Description CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease[1].
Related Catalog
Target

HDAC1:673 nM (IC50, 30 min (time-dependent))

PDE5:114 nM nM (IC50)

In Vitro CM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours) [1].
References

[1]. Rabal O, et al. Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors. ACS Chem Neurosci. 2019 Mar 20;10(3):1765-1782.

Molecular Formula C31H32N6O3
Molecular Weight 536.62