CM-675
Modify Date: 2024-01-08 18:08:26
CM-675 structure
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Common Name | CM-675 | ||
|---|---|---|---|---|
| CAS Number | 1872466-47-1 | Molecular Weight | 536.62 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H32N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CM-675CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease[1]. |
| Name | CM-675 |
|---|
| Description | CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease[1]. |
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| Related Catalog | |
| Target |
HDAC1:673 nM (IC50, 30 min (time-dependent)) PDE5:114 nM nM (IC50) |
| In Vitro | CM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours) [1]. |
| References |
| Molecular Formula | C31H32N6O3 |
|---|---|
| Molecular Weight | 536.62 |