1564249-38-2

1564249-38-2 structure

Name: BJE6-106
Chemical Name: BJE6-106
CAS Number: 1564249-38-2
Molecular Formula: C₂₆H₂₃NO₂
Molecular Weight: 381.47
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2019-09-10 10:32:48
Modify Date: 2025-08-22 13:28:35
BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect.

Name	BJE6-106

Description	BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect.
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKCδ:0.05 μM (IC50) PKCα:50 μM (IC50)
In Vitro	BJE6-106 (B106) (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations[1]. BJE6-106 (B106) (0.2 μM, 0.5 μM; 6-24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells[1]. BJE6-106 (B106) (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing MKK4, JNK and H2AX activation at different times in SBcl2 cells[1]. Cell Viability Assay[1] Cell Line: Melanoma cell lines with NRAS mutations: SBcl2, FM6, SKMEL2, WM1366, WM1361A, and WM852 cells Concentration: 0.2 μM, 0.5 μM Incubation Time: 24 hours, 48 hours, or 72 hours Result: Inhibited cell survival in melanoma cell lines. Apoptosis Analysis[1] Cell Line: SBcl2 cells Concentration: 0.2 μM, 0.5 μM Incubation Time: 6 hours, 12 hours, or 24 hours Result: Induced caspase 3/7 activation. Western Blot Analysis[1] Cell Line: SBcl2 cells Concentration: 0.2 μM, 0.5 μM Incubation Time: 2 hours, 5 hours, 10 hours Result: Increased phosphorylation of MKK4, JNK and H2AX.
References	[1]. Takashima A,et al. Protein kinase Cδ is a therapeutic target in malignant melanoma with NRAS mutation. ACS Chem Biol. 2014 Apr 18;9(4):1003-14.

Molecular Formula	C₂₆H₂₃NO₂
Molecular Weight	381.47

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