309935-57-7
309935-57-7 structure
- Name: Tubulysin D
- Chemical Name: Tubulysin D
- CAS Number: 309935-57-7
- Molecular Formula: C43H65N5O9S
- Molecular Weight: 828.07
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2019-09-09 19:48:50
- Modify Date: 2024-01-09 23:02:58
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Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2].
| Name | Tubulysin D |
|---|
| Description | Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2]. |
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| Related Catalog | |
| Target |
IC50: 1.7 μM (Tubulin)[1] |
| In Vitro | Tubulysin D has IC50s of 4.7 pM, 3.1 pM, 670 pM and 13 pM for HL60, HCT116, MCF7, A549 cell lines antiproliferative activity, respectively[1]. |
| References |
| Molecular Formula | C43H65N5O9S |
|---|---|
| Molecular Weight | 828.07 |
| Hazard Codes | Xi |
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