1140517-08-3

1140517-08-3 structure

Name: ML 604440
Chemical Name: ML604440
CAS Number: 1140517-08-3
Molecular Formula: C₁₇H₂₄BF₃N₂O₄
Molecular Weight: 388.19
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2019-10-09 18:15:29
Modify Date: 2025-08-26 19:10:44
ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1].ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].

Name	ML604440

Description	ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1].ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
Target	proteasome β1i (LMP2) subunit inhibitor[1]
References	[1]. de Bruin G, et al. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014 Jul 24;57(14):6197-209 [2]. Basler M, et al. Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep. 2018 Dec;19(12). pii: e46512.

Molecular Formula	C₁₇H₂₄BF₃N₂O₄
Molecular Weight	388.19