ML 604440

Modify Date: 2024-01-10 11:32:15

ML 604440 Structure
ML 604440 structure
 Common Name ML 604440
CAS Number 1140517-08-3 Molecular Weight 388.19
Density N/A Boiling Point N/A
Molecular Formula C17H24BF3N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ML 604440


ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1].ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].

 Names

Name ML604440

 ML 604440 Biological Activity

Description ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1].ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].
Related Catalog
Target

proteasome β1i (LMP2) subunit inhibitor[1]

References

[1]. de Bruin G, et al. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014 Jul 24;57(14):6197-209

[2]. Basler M, et al. Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep. 2018 Dec;19(12). pii: e46512.

 Chemical & Physical Properties

Molecular Formula C17H24BF3N2O4
Molecular Weight 388.19
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Chemsrc provides ML 604440(CAS#:1140517-08-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ML 604440 are included as well.>> amp version: ML 604440

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