167011-22-5
167011-22-5 structure
- Name: CP-96021 hydrochloride
- Chemical Name: CP-96021 hydrochloride
- CAS Number: 167011-22-5
- Molecular Formula: C29H22ClFN4OS
- Molecular Weight: 529.03
- Create Date: 2019-12-08 17:19:32
- Modify Date: 2024-01-09 23:18:27
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CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively[1].
| Name | CP-96021 hydrochloride |
|---|
| Description | CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively[1]. |
|---|---|
| Target |
LTC4:34 nM (Ki) Platelet activating factor (PAF) receptor:37 nM (Ki) |
| In Vivo | In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with an ED50s of 1.8 mg/kg p.o[1]. |
| References |
| Molecular Formula | C29H22ClFN4OS |
|---|---|
| Molecular Weight | 529.03 |