CP-96021 hydrochloride

Modify Date: 2024-01-09 23:18:27

CP-96021 hydrochloride Structure
CP-96021 hydrochloride structure
Common Name CP-96021 hydrochloride
CAS Number 167011-22-5 Molecular Weight 529.03
Density N/A Boiling Point N/A
Molecular Formula C29H22ClFN4OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CP-96021 hydrochloride


CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively[1].

 Names

Name CP-96021 hydrochloride

 CP-96021 hydrochloride Biological Activity

Description CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively[1].
Target

LTC4:34 nM (Ki)

Platelet activating factor (PAF) receptor:37 nM (Ki)

In Vivo In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with an ED50s of 1.8 mg/kg p.o[1].
References

[1]. A. Marfat, et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 1995, 5 (13): 1377-1382.

 Chemical & Physical Properties

Molecular Formula C29H22ClFN4OS
Molecular Weight 529.03