CP-96021 hydrochloride structure
|
Common Name | CP-96021 hydrochloride | ||
---|---|---|---|---|
CAS Number | 167011-22-5 | Molecular Weight | 529.03 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C29H22ClFN4OS | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of CP-96021 hydrochlorideCP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively[1]. |
Name | CP-96021 hydrochloride |
---|
Description | CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively[1]. |
---|---|
Target |
LTC4:34 nM (Ki) Platelet activating factor (PAF) receptor:37 nM (Ki) |
In Vivo | In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with an ED50s of 1.8 mg/kg p.o[1]. |
References |
Molecular Formula | C29H22ClFN4OS |
---|---|
Molecular Weight | 529.03 |