1639220-17-9

1639220-17-9 structure

Name: Sigma-1 receptor antagonist 3
Chemical Name: Sigma-1 receptor antagonist 3
CAS Number: 1639220-17-9
Molecular Formula: C₁₉H₂₃ClFN₃O
Molecular Weight: 363.86
Create Date: 2019-12-09 10:11:32
Modify Date: 2023-01-15 11:05:09
Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 is for treating neuropathic pain[1].

Name	Sigma-1 receptor antagonist 3

Description	Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 is for treating neuropathic pain[1].
Target	IC50: 1.54μM (hERG)[1]. Ki : 1.14 nM (Sigma-1 receptor); 1239 nM (Sigma-2 receptor) [1]
References	[1]. Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.

Molecular Formula	C₁₉H₂₃ClFN₃O
Molecular Weight	363.86