Sigma-1 receptor antagonist 3
Modify Date: 2025-09-01 09:51:12
Sigma-1 receptor antagonist 3 structure
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Common Name | Sigma-1 receptor antagonist 3 | ||
|---|---|---|---|---|
| CAS Number | 1639220-17-9 | Molecular Weight | 363.86 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H23ClFN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Sigma-1 receptor antagonist 3Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 is for treating neuropathic pain[1]. |
| Name | Sigma-1 receptor antagonist 3 |
|---|
| Description | Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 is for treating neuropathic pain[1]. |
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| Target |
IC50: 1.54μM (hERG)[1]. Ki : 1.14 nM (Sigma-1 receptor); 1239 nM (Sigma-2 receptor) [1] |
| References |
| Molecular Formula | C19H23ClFN3O |
|---|---|
| Molecular Weight | 363.86 |
| InChIKey | OAIHSWLLDNASTO-UHFFFAOYSA-N |
| SMILES | Cc1nc(-c2ccc(F)cc2)nc(OCCCN2CCCCC2)c1Cl |