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1135270-45-9

1135270-45-9 structure
1135270-45-9 structure
  • Name: HG-7-27-01
  • Chemical Name: N-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-[(E)-2-(5-{[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino}-2-pyrazinyl)vinyl]benzamide
  • CAS Number: 1135270-45-9
  • Molecular Formula: C37H43F3N10O
  • Molecular Weight: 700.799
  • Create Date: 2020-01-12 08:17:50
  • Modify Date: 2024-04-03 19:47:16
  • HG-7-27-01 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 224 nM, displays intermediate selectivity profiles (selectivity score=0.16) against 442 kinases.

Name N-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-[(E)-2-(5-{[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino}-2-pyrazinyl)vinyl]benzamide
Synonyms N-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-[(E)-2-(5-{[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino}-2-pyrazinyl)vinyl]benzamide
Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(E)-2-[5-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-2-pyrazinyl]ethenyl]-
Description HG-7-27-01 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 224 nM, displays intermediate selectivity profiles (selectivity score=0.16) against 442 kinases.
References References 1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40. View Related Products by Target c-Fes Kinase
Density 1.3±0.1 g/cm3
Boiling Point 754.0±60.0 °C at 760 mmHg
Molecular Formula C37H43F3N10O
Molecular Weight 700.799
Flash Point 409.8±32.9 °C
Exact Mass 700.357361
LogP 4.64
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.646