161416-61-1

161416-61-1 structure

Name: ABT 089 2HCl
Chemical Name: ABT-089 dihydrochloride
CAS Number: 161416-61-1
Molecular Formula: C₁₁H₁₆N₂O_.2HCl
Molecular Weight: 265.179
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2020-01-19 20:03:55
Modify Date: 2025-08-27 08:30:46
A potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR; displays a similar potency and efficacy to (-)-nicotine to facilitate ACh release (EC50=3 uM), with less potent and less efficacious stimulate dopamine release (ABT-089, EC50=1.1 uM; (-)-nicotine, EC50=0.04 uM); shows effects on cognitive performance in rats and monkeys. Alzheimer Disease Phase 2 Discontinued

Name	ABT-089 dihydrochloride
Synonyms	2-Methyl-3-[(2S)-2-pyrrolidinylmethoxy]pyridine dihydrochloride MFCD00929191 Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, hydrochloride (1:2) 2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride POZANICLINE DIHYDROCHLORIDE ABT-089 dihydrochloride

Description	A potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR; displays a similar potency and efficacy to (-)-nicotine to facilitate ACh release (EC50=3 uM), with less potent and less efficacious stimulate dopamine release (ABT-089, EC50=1.1 uM; (-)-nicotine, EC50=0.04 uM); shows effects on cognitive performance in rats and monkeys. Alzheimer Disease Phase 2 Discontinued
References	References 1. Lin NH, et al. J Med Chem. 1997 Jan 31;40(3):385-90. 2. Sullivan JP, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. 3. Decker MW, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):247-58. View Related Products by Target nAChR Alzheimer Disease

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport