ABT 089 2HCl

Modify Date: 2024-01-15 17:36:56

ABT 089 2HCl structure	Common Name	ABT 089 2HCl
	CAS Number	161416-61-1	Molecular Weight	265.179
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₆N₂O_.2HCl	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of ABT 089 2HCl

A potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR; displays a similar potency and efficacy to (-)-nicotine to facilitate ACh release (EC50=3 uM), with less potent and less efficacious stimulate dopamine release (ABT-089, EC50=1.1 uM; (-)-nicotine, EC50=0.04 uM); shows effects on cognitive performance in rats and monkeys. Alzheimer Disease Phase 2 Discontinued

Name	ABT-089 dihydrochloride
Synonym	More Synonyms

Description	A potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR; displays a similar potency and efficacy to (-)-nicotine to facilitate ACh release (EC50=3 uM), with less potent and less efficacious stimulate dopamine release (ABT-089, EC50=1.1 uM; (-)-nicotine, EC50=0.04 uM); shows effects on cognitive performance in rats and monkeys. Alzheimer Disease Phase 2 Discontinued
References	References 1. Lin NH, et al. J Med Chem. 1997 Jan 31;40(3):385-90. 2. Sullivan JP, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. 3. Decker MW, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):247-58. View Related Products by Target nAChR Alzheimer Disease

Description

References

References 1. Lin NH, et al. J Med Chem. 1997 Jan 31;40(3):385-90. 2. Sullivan JP, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. 3. Decker MW, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):247-58. View Related Products by Target nAChR Alzheimer Disease

Molecular Formula	C₁₁H₁₆N₂O_.2HCl
Molecular Weight	265.179
Exact Mass	264.079620

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport

2-Methyl-3-[(2S)-2-pyrrolidinylmethoxy]pyridine dihydrochloride

MFCD00929191

Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, hydrochloride (1:2)

2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride

POZANICLINE DIHYDROCHLORIDE

ABT-089 dihydrochloride

DC Chemicals Limited
China
Product Name: ABT 089 dihydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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