145757-50-2
145757-50-2 structure
- Name: ALLM (Calpain Inhibitor)
- Chemical Name: 7693643
- CAS Number: 145757-50-2
- Molecular Formula: C19H35N3O4S1
- Molecular Weight: 401.564
- Create Date: 2020-01-11 12:07:29
- Modify Date: 2024-09-02 16:20:36
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ALLM (Calpain Inhibitor) is cell-permeable, peptide aldehyde inhibitor of calpains and cathepsins.
| Name | 7693643 |
|---|---|
| Synonyms |
N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxo-2-butanyl]-L-leucinamide
N-Acetyl-L-leucyl-L-leucyl-L-methioninal SUAM-312 Calpain inhibitor II L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]- MFCD00065506 N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxobutan-2-yl]-L-leucinamide 1D8SBU367Z |
| Description | ALLM (Calpain Inhibitor) is cell-permeable, peptide aldehyde inhibitor of calpains and cathepsins. |
|---|---|
| In Vitro | ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki = 120 nM) and calpain II (Ki = 230 nM). ALLM acts as a very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome. For the detailed information of ALLM (Calpain Inhibitor), the solubility of ALLM (Calpain Inhibitor) in water, the solubility of ALLM (Calpain Inhibitor) in DMSO, the solubility of ALLM (Calpain Inhibitor) in PBS buffer, the animal experiment (test) of ALLM (Calpain Inhibitor), the cell expriment (test) of ALLM (Calpain Inhibitor), the in vivo, in vitro and clinical trial test of ALLM (Calpain Inhibitor), the EC50, IC50,and affinity,of ALLM (Calpain Inhibitor), For the detailed information of ALLM (Calpain Inhibitor), the solubility of ALLM (Calpain Inhibitor) in water, the solubility of ALLM (Calpain Inhibitor) in DMSO, the solubility of ALLM (Calpain Inhibitor) in PBS buffer, the animal experiment (test) of ALLM (Calpain Inhibitor), the cell expriment (test) of ALLM (Calpain Inhibitor), the in vivo, in vitro and clinical trial test of ALLM (Calpain Inhibitor), the EC50, IC50,and affinity,of ALLM (Calpain Inhibitor), Please contact DC Chemicals. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 676.5±55.0 °C at 760 mmHg |
| Molecular Formula | C19H35N3O4S1 |
| Molecular Weight | 401.564 |
| Flash Point | 362.9±31.5 °C |
| Exact Mass | 401.234833 |
| LogP | 2.64 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.496 |