110115-07-6

110115-07-6 structure

Name: ALLM
Chemical Name: calpain inhibitor ii
CAS Number: 110115-07-6
Molecular Formula: C₁₉H₃₅N₃O₄S
Molecular Weight: 401.564
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
Create Date: 2018-12-26 18:12:39
Modify Date: 2024-01-03 20:43:37
ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].

Name	calpain inhibitor ii
Synonyms	N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxo-2-butanyl]-L-leucinamide N-AC-LEU-LEU-METHIONINAL AC-LEU-LEU-L-METHIONINAL L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]- Ac-Leu-Leu-Met-al N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxobutan-2-yl]-L-leucinamide ALLM AC-LEU-LEU-MET-ALDEHYDE AC-LEU-LEU-METHIONINAL AC-LEU-LEU-MET-CHO N-ACETYL-LEU-LEU-MET-CHO MFCD00065506 AC-LLM-CHO

Description	ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
In Vivo	ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death[2]. ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)[2]. Animal Model: Adult male Wistar rats (280-300g) (spinal cord injury model)[2] Dosage: 0.05, 0.5, and 2.5 mg/kg Administration: Intraperitoneally; every 24 h for 1 week Result: Showed significantly better motor function.
References	[1]. Stangl V, et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J. 2004 Feb;18(2):272-9. [2]. Arataki S, et al. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J Neurotrauma. 2005 Mar;22(3):398-406.