862811-76-5

862811-76-5 structure

Name: DRV1 (GPR32) agonist C2A
Chemical Name: 3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide
CAS Number: 862811-76-5
Molecular Formula: C₂₀H₁₄F₂N₄O
Molecular Weight: 364.348
Create Date: 2020-01-11 13:04:49
Modify Date: 2025-08-24 15:48:45
DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively; elicits rapid impedance changes in cells overexpressing recombinant DRV1, stimulates phagocytosis of serum-treated zymosan at concentrations comparable with that of RvD1, the endogenous DRV1 ligand, in human macrophages; also significantly increases by these chemotypes in DRV1-transfected macrophages in live E. coli.

Name	3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide
Synonyms	Benzamide, 3,4-difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]- 3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide

Description	DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively; elicits rapid impedance changes in cells overexpressing recombinant DRV1, stimulates phagocytosis of serum-treated zymosan at concentrations comparable with that of RvD1, the endogenous DRV1 ligand, in human macrophages; also significantly increases by these chemotypes in DRV1-transfected macrophages in live E. coli.
References	References 1. Chiang N, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30383-0. View Related Products by Target Other Targets