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  • DC Chemicals Limited
  • China
  • Product Name: PBD-150
  • Price: $550.0/100mg $950.0/250mg $1900.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

790663-33-1

790663-33-1 structure
790663-33-1 structure
  • Name: PBD-150
  • Chemical Name: PBD-150
  • CAS Number: 790663-33-1
  • Molecular Formula: C15H20N4O2S
  • Molecular Weight: 320.411
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2020-01-20 16:34:56
  • Modify Date: 2024-01-09 08:23:39
  • A potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM; significantly reduces depositions of Aβ3(pGlu)-40/42 in brain in transgenic mouse models and Drosophila model of Alzheimer diseas.

Name PBD-150
Description A potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM; significantly reduces depositions of Aβ3(pGlu)-40/42 in brain in transgenic mouse models and Drosophila model of Alzheimer diseas.
Related Catalog
In Vivo PBD-150 is able to reduce the deposition of pyroglutamate-modified amyloid-β peptides in brain of transgenic mouse models of Alzheimer disease, leading to a significant improvement of learning and memory in those transgenic animals[3].
References

[1]. Buchholz M, et al. The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem. 2006 Jan 26;49(2):664-77.

[2]. DiPisa F, et al. The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):986-92.

[3]. Huang KF, et al. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. J Biol Chem. 2011 Apr 8;286(14):12439-49.

Molecular Formula C15H20N4O2S
Molecular Weight 320.411