1237540-74-7
1237540-74-7 structure
- Name: NC-005
- Chemical Name: NC-005
- CAS Number: 1237540-74-7
- Molecular Formula: C40H45N3O6
- Molecular Weight: 663.815
- Create Date: 2020-01-11 15:48:50
- Modify Date: 2022-11-21 13:57:12
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A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely; shows cytotoxicity against multiple myeloma cells with IC50 of 30 nM-1.5 uM.
| Name | NC-005 |
|---|
| Description | A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely; shows cytotoxicity against multiple myeloma cells with IC50 of 30 nM-1.5 uM. |
|---|---|
| References | References 1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89. 2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209. View Related Products by Target Proteasome |
| Molecular Formula | C40H45N3O6 |
|---|---|
| Molecular Weight | 663.815 |