NC-005
Modify Date: 2025-11-28 18:25:15
NC-005 structure
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Common Name | NC-005 | ||
|---|---|---|---|---|
| CAS Number | 1237540-74-7 | Molecular Weight | 663.815 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H45N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NC-005A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely; shows cytotoxicity against multiple myeloma cells with IC50 of 30 nM-1.5 uM. |
| Name | NC-005 |
|---|
| Description | A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely; shows cytotoxicity against multiple myeloma cells with IC50 of 30 nM-1.5 uM. |
|---|---|
| References | References 1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89. 2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209. View Related Products by Target Proteasome |
| Molecular Formula | C40H45N3O6 |
|---|---|
| Molecular Weight | 663.815 |
| InChIKey | GSZQNUFPKJVERP-BHRDRLSISA-N |
| SMILES | COc1ccc(CC(NC(=O)Cc2ccc3ccccc3c2)C(=O)NC(Cc2ccccc2)C(=O)NC(CC(C)C)C(=O)C2(C)CO2)cc1 |