1350296-29-5
1350296-29-5 structure
- Name: CM 764
- Chemical Name: CM 764
- CAS Number: 1350296-29-5
- Molecular Formula: C23H27FN4O3
- Molecular Weight: 426.492
- Create Date: 2020-01-20 07:08:57
- Modify Date: 2025-08-25 22:35:02
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A potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM); increases reduction of MTT in human SK-N-SH neuroblastoma, produces an immediate, robust, and transient increase in cytosolic calcium, consistent with sigma-2 receptor activation; increases total NAD(+)/NADH level, the ATP level, HIF1α and VEGF levelsin SK-N-SH cells.
| Name | CM 764 |
|---|
| Description | A potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM); increases reduction of MTT in human SK-N-SH neuroblastoma, produces an immediate, robust, and transient increase in cytosolic calcium, consistent with sigma-2 receptor activation; increases total NAD(+)/NADH level, the ATP level, HIF1α and VEGF levelsin SK-N-SH cells. |
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| References | References 1. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. View Related Products by Target Sigma Receptor |
| Molecular Formula | C23H27FN4O3 |
|---|---|
| Molecular Weight | 426.492 |