Name | CM 764 |
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Description | A potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM); increases reduction of MTT in human SK-N-SH neuroblastoma, produces an immediate, robust, and transient increase in cytosolic calcium, consistent with sigma-2 receptor activation; increases total NAD(+)/NADH level, the ATP level, HIF1α and VEGF levelsin SK-N-SH cells. |
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References | References 1. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. View Related Products by Target Sigma Receptor |
Molecular Formula | C23H27FN4O3 |
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Molecular Weight | 426.492 |