CM 764

Modify Date: 2024-01-18 11:09:07

CM 764 Structure
CM 764 structure
Common Name CM 764
CAS Number 1350296-29-5 Molecular Weight 426.492
Density N/A Boiling Point N/A
Molecular Formula C23H27FN4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CM 764


A potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM); increases reduction of MTT in human SK-N-SH neuroblastoma, produces an immediate, robust, and transient increase in cytosolic calcium, consistent with sigma-2 receptor activation; increases total NAD(+)/NADH level, the ATP level, HIF1α and VEGF levelsin SK-N-SH cells.

 Names

Name CM 764

 CM 764 Biological Activity

Description A potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM); increases reduction of MTT in human SK-N-SH neuroblastoma, produces an immediate, robust, and transient increase in cytosolic calcium, consistent with sigma-2 receptor activation; increases total NAD(+)/NADH level, the ATP level, HIF1α and VEGF levelsin SK-N-SH cells.
References References 1. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. View Related Products by Target Sigma Receptor

 Chemical & Physical Properties

Molecular Formula C23H27FN4O3
Molecular Weight 426.492
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