ADAMTS-5 inhibitor 15f

Modify Date: 2024-01-23 15:43:07

ADAMTS-5 inhibitor 15f Structure
ADAMTS-5 inhibitor 15f structure
Common Name ADAMTS-5 inhibitor 15f
CAS Number 1394122-49-6 Molecular Weight 541.719
Density N/A Boiling Point N/A
Molecular Formula C26H39N9O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ADAMTS-5 inhibitor 15f


ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation.

 Names

Name ADAMTS-5 inhibitor 15f

 ADAMTS-5 inhibitor 15f Biological Activity

Description ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation.
References References 1. Deng H, et al. J Med Chem. 2012 Aug 23;55(16):7061-79. View Related Products by Target Matrix Metalloproteinase (MMP)

 Chemical & Physical Properties

Molecular Formula C26H39N9O2S
Molecular Weight 541.719
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