ADAMTS-5 inhibitor 15f
Modify Date: 2024-01-23 15:43:07
ADAMTS-5 inhibitor 15f structure
|
Common Name | ADAMTS-5 inhibitor 15f | ||
|---|---|---|---|---|
| CAS Number | 1394122-49-6 | Molecular Weight | 541.719 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H39N9O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ADAMTS-5 inhibitor 15fADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation. |
| Name | ADAMTS-5 inhibitor 15f |
|---|
| Description | ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation. |
|---|---|
| References | References 1. Deng H, et al. J Med Chem. 2012 Aug 23;55(16):7061-79. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Molecular Formula | C26H39N9O2S |
|---|---|
| Molecular Weight | 541.719 |