1448314-00-8
1448314-00-8 structure
- Name: MCT1-IN-4a
- Chemical Name: MCT1-IN-4a
- CAS Number: 1448314-00-8
- Molecular Formula: C24H19NO4
- Molecular Weight: 385.419
- Create Date: 2020-01-16 13:30:02
- Modify Date: 2024-04-07 17:57:17
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MCT1-IN-4a is a potent, selective monocarboxylate transporter 1 (MCT1) inhibitor with IC50 of 90 nM; exhibits significant single agent activity in MCT1 expressing GL261-luc2 syngraft model, but not in MCT4 expressing MDA-MB-231 xenograft model; has good absorption, metabolic stability, and a low drug efflux ratio.
| Name | MCT1-IN-4a |
|---|
| Description | MCT1-IN-4a is a potent, selective monocarboxylate transporter 1 (MCT1) inhibitor with IC50 of 90 nM; exhibits significant single agent activity in MCT1 expressing GL261-luc2 syngraft model, but not in MCT4 expressing MDA-MB-231 xenograft model; has good absorption, metabolic stability, and a low drug efflux ratio. |
|---|---|
| References | References 1. Gurrapu S, et al. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3282-6. View Related Products by Target Monocarboxylate Transporter (MCT) |
| Molecular Formula | C24H19NO4 |
|---|---|
| Molecular Weight | 385.419 |