Name | LSD1-IN-32 |
---|
Description | LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM; display much greater levels of selectivity over the hERG cardiac ion channel than GSK-690; shows significant anti-proliferative activity, promotes the differentiation of AML cells, with concomitant reduction in clonogenic potential. |
---|---|
References | References 1. Mould DP, et al. J Med Chem. 2017 Oct 12;60(19):7984-7999. View Related Products by Target Histone Demethylase |
Molecular Formula | C24H27FN4O2 |
---|---|
Molecular Weight | 422.504 |