2137044-49-4
2137044-49-4 structure
- Name: LSD1-IN-32
- Chemical Name: LSD1-IN-32
- CAS Number: 2137044-49-4
- Molecular Formula: C24H27FN4O2
- Molecular Weight: 422.504
- Create Date: 2020-01-12 11:39:45
- Modify Date: 2024-04-04 19:34:22
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LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM; display much greater levels of selectivity over the hERG cardiac ion channel than GSK-690; shows significant anti-proliferative activity, promotes the differentiation of AML cells, with concomitant reduction in clonogenic potential.
| Name | LSD1-IN-32 |
|---|
| Description | LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM; display much greater levels of selectivity over the hERG cardiac ion channel than GSK-690; shows significant anti-proliferative activity, promotes the differentiation of AML cells, with concomitant reduction in clonogenic potential. |
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| References | References 1. Mould DP, et al. J Med Chem. 2017 Oct 12;60(19):7984-7999. View Related Products by Target Histone Demethylase |
| Molecular Formula | C24H27FN4O2 |
|---|---|
| Molecular Weight | 422.504 |