2241325-66-4
2241325-66-4 structure
- Name: GAK inhibitor 12r
- Chemical Name: GAK inhibitor 12r
- CAS Number: 2241325-66-4
- Molecular Formula: C19H22N4O2S
- Molecular Weight: 370.471
- Create Date: 2020-01-20 06:16:55
- Modify Date: 2024-01-11 19:08:18
-
GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM; targets only 8 other kinases with greater than 90% inhibition in a diverse panel of 468 kinases; demonstrates broad-spectrum antiviral activity with EC50 of 0.82 uM against DENV-2, also shows activity against dengue virus, including in human primary dendritic cells, and efficacy against the unrelated Ebola and chikungunya viruses.
| Name | GAK inhibitor 12r |
|---|
| Description | GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM; targets only 8 other kinases with greater than 90% inhibition in a diverse panel of 468 kinases; demonstrates broad-spectrum antiviral activity with EC50 of 0.82 uM against DENV-2, also shows activity against dengue virus, including in human primary dendritic cells, and efficacy against the unrelated Ebola and chikungunya viruses. |
|---|---|
| References | References 1. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613. View Related Products by Target Other Targets |
| Molecular Formula | C19H22N4O2S |
|---|---|
| Molecular Weight | 370.471 |