GAK inhibitor 12r
Modify Date: 2024-01-11 19:08:18
GAK inhibitor 12r structure
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Common Name | GAK inhibitor 12r | ||
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| CAS Number | 2241325-66-4 | Molecular Weight | 370.471 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H22N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GAK inhibitor 12rGAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM; targets only 8 other kinases with greater than 90% inhibition in a diverse panel of 468 kinases; demonstrates broad-spectrum antiviral activity with EC50 of 0.82 uM against DENV-2, also shows activity against dengue virus, including in human primary dendritic cells, and efficacy against the unrelated Ebola and chikungunya viruses. |
| Name | GAK inhibitor 12r |
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| Description | GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM; targets only 8 other kinases with greater than 90% inhibition in a diverse panel of 468 kinases; demonstrates broad-spectrum antiviral activity with EC50 of 0.82 uM against DENV-2, also shows activity against dengue virus, including in human primary dendritic cells, and efficacy against the unrelated Ebola and chikungunya viruses. |
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| References | References 1. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613. View Related Products by Target Other Targets |
| Molecular Formula | C19H22N4O2S |
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| Molecular Weight | 370.471 |