2346614-58-0
2346614-58-0 structure
- Name: IDO1-IN-2
- Chemical Name: IDO1-IN-2
- CAS Number: 2346614-58-0
- Molecular Formula: C15H17FN6O4
- Molecular Weight: 364.33
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Indoleamine 2,3-Dioxygenase (IDO)
- Create Date: 2020-04-16 18:16:15
- Modify Date: 2024-01-16 14:13:58
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IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity[1].
| Name | IDO1-IN-2 |
|---|
| Description | IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity[1]. |
|---|---|
| Related Catalog | |
| Target |
IDO1:81 nM (IC50) |
| In Vitro | IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC50 of 49 nM. IDO1-IN-2 has an IC50 of 249 nM for IDO1 wholr blood[1]. |
| In Vivo | IDO1-IN-2 (100 mg/kg, twice daily) demonstrates good efficacy synergy when combined with anti-PD-1 mAb in a mouse EMT6 tumor syngeneic model[1]. IDO1-IN-2 has a t1/2 of 3.7 hours, a CL/CLu of 15/319 mL/min/kg, and a F of 63% for rats. IDO1-IN-2 has a t1/2 of 6 hours, a CL/CLu of 6/88 mL/min/kg, and a F of 67% for dogs[1]. |
| References |
| Molecular Formula | C15H17FN6O4 |
|---|---|
| Molecular Weight | 364.33 |