IDO1-IN-2

Modify Date: 2024-01-16 14:13:58

IDO1-IN-2 structure	Common Name	IDO1-IN-2
	CAS Number	2346614-58-0	Molecular Weight	364.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₇FN₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IDO1-IN-2

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity[1].

Name	IDO1-IN-2

Description	IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO) Research Areas >> Inflammation/Immunology
Target	IDO1:81 nM (IC50)
In Vitro	IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC50 of 49 nM. IDO1-IN-2 has an IC50 of 249 nM for IDO1 wholr blood[1].
In Vivo	IDO1-IN-2 (100 mg/kg, twice daily) demonstrates good efficacy synergy when combined with anti-PD-1 mAb in a mouse EMT6 tumor syngeneic model[1]. IDO1-IN-2 has a t1/2 of 3.7 hours, a CL/CLu of 15/319 mL/min/kg, and a F of 63% for rats. IDO1-IN-2 has a t1/2 of 6 hours, a CL/CLu of 6/88 mL/min/kg, and a F of 67% for dogs[1].
References	[1]. Zhang H, et al.Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.ACS Med Chem Lett. 2019 Sep 18;10(11):1530-1536.

Molecular Formula	C₁₅H₁₇FN₆O₄
Molecular Weight	364.33

DC Chemicals Limited
China
Product Name: IDO1-IN-2
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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