2127109-85-5
2127109-85-5 structure
- Name: Tyk2-IN-9
- Chemical Name: Tyk2-IN-9
- CAS Number: 2127109-85-5
- Molecular Formula: C20H17N9
- Molecular Weight: 383.41
- Catalog: Signaling Pathways Epigenetics JAK
- Create Date: 2020-04-08 23:32:04
- Modify Date: 2024-01-14 10:20:20
-
Tyk2-IN-9 is a potent,selective and specific inhibitor of JAK kinases, inhibits Tyk2, JAK1 and JAK2 with IC50 values of 6 nM, 21nM and 6nM, respectively. Tyk2-IN-9, example 19, is extracted from patent US2017240552A1[1].
| Name | Tyk2-IN-9 |
|---|
| Description | Tyk2-IN-9 is a potent,selective and specific inhibitor of JAK kinases, inhibits Tyk2, JAK1 and JAK2 with IC50 values of 6 nM, 21nM and 6nM, respectively. Tyk2-IN-9, example 19, is extracted from patent US2017240552A1[1]. |
|---|---|
| Related Catalog | |
| Target |
Tyk2:6 nM (IC50) JAK1:21 nM (IC50) JAK2:8 nM (IC50) |
| In Vitro | Tyk2-IN-9 has the ability to inhibit IL-12 signaling in a human whole blood with an IC50 value of 28 nM in a flow cytometry assay[1]. |
| References |
[1]. Matthew Frank Brown, et al. Pyrazolo[1,5-a]pyrazin-4-yl derivatives. Patent US20170240552A1 |
| Molecular Formula | C20H17N9 |
|---|---|
| Molecular Weight | 383.41 |