1594986-04-5

1594986-04-5 structure

1594986-04-5 structure

Name: Iodoacetamide-PEG3-azide
Chemical Name: Iodoacetamide-PEG3-azide
CAS Number: 1594986-04-5
Molecular Formula: C₁₀H₁₉IN₄O₄
Molecular Weight: 386.19
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 08:09:51
Modify Date: 2024-01-10 22:26:41
Iodoacetamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Iodoacetamide-PEG3-azide

Description	Iodoacetamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₀H₁₉IN₄O₄
Molecular Weight	386.19