1222765-97-0
1222765-97-0 structure
- Name: NCT-504
- Chemical Name: NCT-504
- CAS Number: 1222765-97-0
- Molecular Formula: C15H12N6O2S3
- Molecular Weight: 404.49
- Catalog: Research Areas Neurological Disease
- Create Date: 2020-06-01 17:42:18
- Modify Date: 2024-01-06 18:24:45
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NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC50 of 15.8 μM. NCT-504 is potential for the research of Huntington's disease[1].
| Name | NCT-504 |
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| Description | NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC50 of 15.8 μM. NCT-504 is potential for the research of Huntington's disease[1]. |
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| Related Catalog | |
| Target |
IC50: 15.8 μM (PIP4Kγ)[1] |
| In Vitro | NCT-504 dose not impair the intrinsic ATP-hydrolytic activity of PIP4Kγ in the absence of PI5P substrate[1]. NCT-504 does not inhibit PIP4Kbeta and weakly inhibits PIP4Kalpha phosphorylation of PI5P [1]. NCT-504 dose not inhibit PIP4Kbeta or PIP4Kalpha (IC50 between 50 μM and 100 μM) at 50 μM concentration[1]. NCT-504 elevates the levels of PI(3,5)P2, PI3P and PI5P in MEFs[1]. NCT-504 (10 μM; 12 hours) does not affect cell viability in MEFs[1]. NCT-504 (5 μM, 10 μM; 2 hours, 6 hours) elevates both the induction of autophagy as well as the rate of turnover of autophagic cargo[1]. NCT-504 treatment causes a robust increase in the formation of autolysosomes with only a modest elevation in autophagosomes[1]. NCT-504 increases autophagy flux and decreases huntingtin protein in 293A cells[1]. NCT-504 reduces mHtt protein levels in immortalized striatal cells from knock-in HD mice[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 5 μM, 10 μM Incubation Time: 2 hours, 6 hours Result: Induced autophagosome formation. |
| References |
| Molecular Formula | C15H12N6O2S3 |
|---|---|
| Molecular Weight | 404.49 |