2341796-75-4

2341796-75-4 structure

Name: (S,R,S)-AHPC-C10-NH2 dihydrochloride
Chemical Name: (S,R,S)-AHPC-C10-NH2 dihydrochloride
CAS Number: 2341796-75-4
Molecular Formula: C₃₃H₅₃Cl₂N₅O₄S
Molecular Weight: 686.78
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 18:03:43
Modify Date: 2024-04-02 13:44:37
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC[1].

Name	(S,R,S)-AHPC-C10-NH2 dihydrochloride

Description	(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	VHL
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.