2393840-15-6
2393840-15-6 structure
- Name: LEI-401
- Chemical Name: LEI-401
- CAS Number: 2393840-15-6
- Molecular Formula: C24H31N5O2
- Molecular Weight: 421.54
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
- Create Date: 2020-08-07 11:18:38
- Modify Date: 2024-01-16 19:04:59
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LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice[1].
| Name | LEI-401 |
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| Description | LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice[1]. |
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| Related Catalog | |
| In Vitro | LEI-401 reduced a broad range of NAEs including anandamide in neuronal cells in a NAPE-PLD-dependent manner. LEI-401 (0.04-20 μM; 30 minutes) dose-dependently reduces the labeling of NAPE-PLD with an IC50 of 0.86 μM in hNAPE-PLD-transfected HEK293T cells. LEI-401 reduces NAE levels in Neuro-2a cells, but not in NAPE-PLD KO cells[1]. |
| In Vivo | LEI-401 (30 mg/kg; i.p.) diminishes fear extinction in mice[1]. LEI-401 also activates HPA axis signaling[1]. LEI-401 (10 mg/kg; p.o.) treatment shows the t1/2, Cmax, tmax, AUClast, and F values of 2.5 hours, 1370 ng/mL, 2 hours, 6760 h*ng/mL, and 25%, respectively[1]. LEI-401 (30 mg/kg; i.p.) treatment show the Cmax, tmax, AUClast, and F values of 10300 ng/mL, 1 hour, 38600 h*ng/mL, and 48%, respectively[1]. Animal Model: Male 7–12-week-old C57BL/6J mice[1] Dosage: 30 mg/kg Administration: I.p. Result: Produced a significant increase in freezing as compared to vehicle. Animal Model: C57BL/6J mice[1] Dosage: 10 mg/kg Administration: P.o. (Pharmacokinetic Analysis) Result: The t1/2, Cmax, tmax, AUClast, and F values were 2.5 hours, 1370 ng/mL, 2 hours, 6760 h*ng/mL, and 25%, respectively. |
| References |
| Molecular Formula | C24H31N5O2 |
|---|---|
| Molecular Weight | 421.54 |