Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PAD2-IN-1
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

2095109-82-1

2095109-82-1 structure

2095109-82-1 structure

Name: PAD2-IN-1
Chemical Name: PAD2-IN-1
CAS Number: 2095109-82-1
Molecular Formula: C₂₅H₂₉FN₆O₃
Molecular Weight: 480.53
Catalog: Research Areas Inflammation/Immunology
Create Date: 2020-08-08 11:11:29
Modify Date: 2025-08-27 00:56:00
PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].

Name	PAD2-IN-1

Description	PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase
Target	Protein Arginine Deiminase 2 (PAD2)[1]
In Vitro	In the target engagement assay, the EC 50 of PAD2-IN-1 (compound 32a) is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells[1]. PAD2-IN-1 (compound 32a; 1-25 μM) treatment strongly inhibits histone H3 citrullination with an EC 50 of 2.7 μM in HEK293T/PAD2 cells[1].
References	[1]. Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211.

Molecular Formula	C₂₅H₂₉FN₆O₃
Molecular Weight	480.53

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.