2414374-53-9

2414374-53-9 structure
2414374-53-9 structure
  • Name: RET-IN-3
  • Chemical Name: RET-IN-3
  • CAS Number: 2414374-53-9
  • Molecular Formula: C18H21N5O2
  • Molecular Weight: 339.39
  • Create Date: 2020-08-11 17:57:59
  • Modify Date: 2025-08-25 18:32:33
  • RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1].

Name RET-IN-3
Description RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1].
Related Catalog
Target

IC50: 19 nM (RETV804M)[1].

In Vitro RET-IN-3 exhibits 16 and 410 fold selectivity compared to wt-RET and KDR, respectively[1].
References

[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.

Molecular Formula C18H21N5O2
Molecular Weight 339.39
Hazard Codes Xn
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