RET-IN-3

Modify Date: 2025-08-25 18:32:33

RET-IN-3 Structure
RET-IN-3 structure
Common Name RET-IN-3
CAS Number 2414374-53-9 Molecular Weight 339.39
Density N/A Boiling Point N/A
Molecular Formula C18H21N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RET-IN-3


RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1].

 Names

Name RET-IN-3

 RET-IN-3 Biological Activity

Description RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1].
Related Catalog
Target

IC50: 19 nM (RETV804M)[1].

In Vitro RET-IN-3 exhibits 16 and 410 fold selectivity compared to wt-RET and KDR, respectively[1].
References

[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.

 Chemical & Physical Properties

Molecular Formula C18H21N5O2
Molecular Weight 339.39

 Safety Information

Hazard Codes Xn
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