1071676-04-4

1071676-04-4 structure

Name: Angoline hydrochloride
Chemical Name: Angoline hydrochloride
CAS Number: 1071676-04-4
Molecular Formula: C₂₂H₂₂ClNO₅
Molecular Weight: 415.87
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2021-01-08 16:04:19
Modify Date: 2025-08-22 11:45:35
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

Name	Angoline hydrochloride

Description	Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT
Target	IC50: 11.56 μM (IL6/STAT3 signaling pathway)
References	[1]. Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.

Molecular Formula	C₂₂H₂₂ClNO₅
Molecular Weight	415.87

Hazard Codes	Xi