2384184-44-3

2384184-44-3 structure

Name: KB02-JQ1
Chemical Name: KB02-JQ1
CAS Number: 2384184-44-3
Molecular Formula: C₃₈H₄₃Cl₂N₇O₆S
Molecular Weight: 796.76
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2021-01-09 19:40:51
Modify Date: 2024-01-09 15:14:08
KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1[1].

Name	KB02-JQ1

Description	KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD4
In Vitro	KB02-JQ1 (5-40 μM; 24 hours; HEK293T cells) treatment shows concentration-dependent degradation of endogenous BRD4 in HEK293T cells[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 5 μM, 10 μM, 20 Μm or 40 μM Incubation Time: 24 hours Result: Concentration-dependent degradation of endogenous BRD4 in HEK293T cells.
References	[1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.

Molecular Formula	C₃₈H₄₃Cl₂N₇O₆S
Molecular Weight	796.76

Hazard Codes	Xi