| Description |
KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1[1].
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| Related Catalog |
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| Target |
BRD4
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| In Vitro |
KB02-JQ1 (5-40 μM; 24 hours; HEK293T cells) treatment shows concentration-dependent degradation of endogenous BRD4 in HEK293T cells[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 5 μM, 10 μM, 20 Μm or 40 μM Incubation Time: 24 hours Result: Concentration-dependent degradation of endogenous BRD4 in HEK293T cells.
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| References |
[1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.
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