1504588-00-4
1504588-00-4 structure
- Name: alphaSYN-IN-NAB2
- Chemical Name: NAB 2
- CAS Number: 1504588-00-4
- Molecular Formula: C23H20ClN3O
- Molecular Weight: 389.877
- Create Date: 2021-01-29 20:20:58
- Modify Date: 2024-01-16 07:05:51
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NAB2 is a neuron-protective agent. NAB2 strongly and selectively protects diverse cell types from α-syn toxicity. NAB2 promots endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a druggable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking[1].
| Name | NAB 2 |
|---|---|
| Synonyms |
N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)benzimidazole-5-carboxamide
N-(2-Chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide NAB 2 MFCD28976190 1H-Benzimidazole-5-carboxamide, N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)- |
| Description | NAB2 is a neuron-protective agent. NAB2 strongly and selectively protects diverse cell types from α-syn toxicity. NAB2 promots endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a druggable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking[1]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C23H20ClN3O |
| Molecular Weight | 389.877 |
| Exact Mass | 389.129486 |
| LogP | 5.88 |
| Index of Refraction | 1.643 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H413 |
| Precautionary Statements | P280-P305 + P351 + P338-P337 + P313 |
| RIDADR | NONH for all modes of transport |