alphaSYN-IN-NAB2

Modify Date: 2024-01-16 07:05:51

alphaSYN-IN-NAB2 Structure
alphaSYN-IN-NAB2 structure
Common Name alphaSYN-IN-NAB2
CAS Number 1504588-00-4 Molecular Weight 389.877
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C23H20ClN3O Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of alphaSYN-IN-NAB2


NAB2 is a neuron-protective agent. NAB2 strongly and selectively protects diverse cell types from α-syn toxicity. NAB2 promots endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a druggable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking[1].

 Names

Name NAB 2
Synonym More Synonyms

 alphaSYN-IN-NAB2 Biological Activity

Description NAB2 is a neuron-protective agent. NAB2 strongly and selectively protects diverse cell types from α-syn toxicity. NAB2 promots endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a druggable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking[1].
Related Catalog
References

[1]. Tardiff DF, et al. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science. 2013;342(6161):979-983.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Molecular Formula C23H20ClN3O
Molecular Weight 389.877
Exact Mass 389.129486
LogP 5.88
Index of Refraction 1.643

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319-H413
Precautionary Statements P280-P305 + P351 + P338-P337 + P313
RIDADR NONH for all modes of transport

 Synonyms

N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)benzimidazole-5-carboxamide
N-(2-Chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
NAB 2
MFCD28976190
1H-Benzimidazole-5-carboxamide, N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-
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