901230-11-3
901230-11-3 structure
- Name: GNE 9278
- Chemical Name: 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide
- CAS Number: 901230-11-3
- Molecular Formula: C21H27N5O3S
- Molecular Weight: 429.536
- Create Date: 2021-01-26 16:15:19
- Modify Date: 2025-08-27 16:04:51
-
GNE-9278 is a potent and selective NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Mutation of a single residue near the Lurcher motif on GluN1 M3 can convert GNE-9278 modulation from positive to negative, and replacing three AMPAR pre-M1 residues with corresponding NMDAR residues can confer GNE-9278 sensitivity to AMPARs. Modulation by GNE-9278 is state-dependent and significantly alters extracellular domain pharmacology.
| Name | 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide |
|---|---|
| Synonyms |
4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide
Benzenesulfonamide, 4-cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)- |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H27N5O3S |
| Molecular Weight | 429.536 |
| Exact Mass | 429.183472 |
| LogP | 5.24 |
| Index of Refraction | 1.691 |