SIRT6-IN-1

Modify Date: 2024-04-06 12:05:00

SIRT6-IN-1 structure	Common Name	SIRT6-IN-1
	CAS Number	1214468-35-5	Molecular Weight	410.40
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₄N₄O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SIRT6-IN-1

SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells[1].

Name	2,4-Dioxo-N-[4-(3-pyridinyloxy)phenyl]-1,2,3,4-tetrahydro-6-quinazolinesulfonamide
Synonym	More Synonyms

Description	SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Signaling Pathways >> Epigenetics >> Histone Demethylase Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Research Areas >> Metabolic Disease
Target	106 μM and 114 μM (SIRT6/SIRT2)[1]
References	[1]. Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804.

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₉H₁₄N₄O₅S
Molecular Weight	410.40
Exact Mass	410.068481
LogP	1.88
Index of Refraction	1.674

2,4-Dioxo-N-[4-(3-pyridinyloxy)phenyl]-1,2,3,4-tetrahydro-6-quinazolinesulfonamide

6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(3-pyridinyloxy)phenyl]-

MFCD11667663

DC Chemicals Limited
China
Product Name: SIRT6-IN-1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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