Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: dehydrobruceine B
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Purity: 98.0%
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53730-90-8

53730-90-8 structure

Name: dehydrobruceine B
Chemical Name: dehydrobruceine B
CAS Number: 53730-90-8
Molecular Formula: C₂₃H₂₆O₁₁
Molecular Weight: 478.45
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-09-12 18:55:21
Modify Date: 2024-01-10 19:46:11
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2[1].

Name	dehydrobruceine B

Description	Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2
Target	Bax Bcl-xL Bcl-2
In Vitro	Dehydrobruceine B (1 μM; 48 h) 和 Cisplatin (3-18 μM; 48 h) 在 A549 细胞中具有协同作用，致使细胞毒性和凋亡效应[1]。 Dehydrobruceine B (1 μM; 24 h) 在 Cisplatin (3 μM, 6 μM; 24 h) 处理的A549细胞中，诱导胞内 ROS 产生[1]。 Dehydrobruceine B (3 μM, 6 μM; 24 h) 在 Cisplatin (3 μM, 6 μM; 24 h) 处理的A549细胞中，促进线粒体膜电位 (MMP) 的去极化和细胞色素 c 的易位[1]。 Dehydrobruceine B (1 μM; 24 h) 增强 A549 细胞抗凋亡和促凋亡蛋白水平的变化[1]。 Western Blot Analysis[1] Cell Line: A549 cells Concentration: 1 μM; with or without Cisplatin Incubation Time: 48 hours Result: Upregulated the protein level of Bax, while downregulated the levels of Bcl-2 and Bcl-xL. Enhanced caspase activation and PARP cleavage. Apoptosis Analysis[1] Cell Line: A549 cells Concentration: 1 μM; with or without Cisplatin Incubation Time: 48 hours Result: Inhibited cell viability with 9 μM and 18 μM Cisplatin, respectively. Induced cell apoptosis with 3 μM and 6 μM Cisplatin, respectively. Immunofluorescence[1] Cell Line: A549 cells Concentration: 1 μM; with or without 3 μM and 6 μM Cisplatin, respectively Incubation Time: 24 hours Result: Resulted apoptosis-inducing factor (AIF) translocated from cytosol into nucleus dramatically in the co-treatment condition.
References	[1]. Huang Z, et al. Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells. Biomed Pharmacother. 2017 May;89:623-631.

Molecular Formula	C₂₃H₂₆O₁₁
Molecular Weight	478.45

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