142375-60-8
142375-60-8 structure
- Name: FR 139317
- Chemical Name: (R)2-[(R)-2[(S)-2[[1-(hexahydro-1H-azepinyl)] carbonyl] amino-4-methylpentanoyl] amino-3-[3-(1-methyl-1H-indolyl)] propionyl] amino-3-(2-pyridyl) propionic acid
- CAS Number: 142375-60-8
- Molecular Formula: C33H44N6O5
- Molecular Weight: 604.74000
- Create Date: 2018-12-01 11:03:59
- Modify Date: 2025-08-21 19:45:45
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FR 139317 is a highly potent and selective antagonist of ETA endothelin receptor, with Ki values of 1 nM and 7.3 μM for ETA and ETB subtypes, respectively.
| Name | (R)2-[(R)-2[(S)-2[[1-(hexahydro-1H-azepinyl)] carbonyl] amino-4-methylpentanoyl] amino-3-[3-(1-methyl-1H-indolyl)] propionyl] amino-3-(2-pyridyl) propionic acid |
|---|---|
| Synonyms |
4-BMA
1-Bma Or 4-Bma Side chain for iMipe 1-BMA B-METHYLAZETIDIN-2-ONE SS-METHYLAZETIDIN-2-ONE |
| Density | 1.27 g/cm3 |
|---|---|
| Boiling Point | 943.9ºC at 760 mmHg |
| Molecular Formula | C33H44N6O5 |
| Molecular Weight | 604.74000 |
| Flash Point | 524.6ºC |
| Exact Mass | 604.33700 |
| PSA | 145.66000 |
| LogP | 4.52360 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.63 |