1329563-41-8

1329563-41-8 structure

Name: Guaifenesin-d5
Chemical Name: Guaifenesin-d5
CAS Number: 1329563-41-8
Molecular Formula: C₁₀H₉D₅O₄
Molecular Weight: 203.25
Catalog: Research Areas Inflammation/Immunology
Create Date: 2021-10-08 16:17:21
Modify Date: 2024-01-14 15:41:54
Guaifenesin-d5 (Guaiacol glyceryl ether-d5) is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough. Guaifenesin also has narcotic effect[1][2].

Name	Guaifenesin-d5

Description	Guaifenesin-d5 (Guaiacol glyceryl ether-d5) is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough. Guaifenesin also has narcotic effect[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Bennett, S., N. Hoffman, and M. Monga, Ephedrine- and guaifenesin-induced nephrolithiasis. J Altern Complement Med, 2004. 10(6): p. 967-9. [3]. Dicpinigaitis PV, et, al. Effect of guaifenesin on cough reflex sensitivity. Chest. 2003 Dec;124(6):2178-81.

Molecular Formula	C₁₀H₉D₅O₄
Molecular Weight	203.25