Guaifenesin-d5

Modify Date: 2024-01-14 15:41:54

Guaifenesin-d5 Structure
Guaifenesin-d5 structure
Common Name Guaifenesin-d5
CAS Number 1329563-41-8 Molecular Weight 203.25
Density N/A Boiling Point N/A
Molecular Formula C10H9D5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Guaifenesin-d5


Guaifenesin-d5 (Guaiacol glyceryl ether-d5) is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough. Guaifenesin also has narcotic effect[1][2].

 Names

Name Guaifenesin-d5

 Guaifenesin-d5 Biological Activity

Description Guaifenesin-d5 (Guaiacol glyceryl ether-d5) is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough. Guaifenesin also has narcotic effect[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Bennett, S., N. Hoffman, and M. Monga, Ephedrine- and guaifenesin-induced nephrolithiasis. J Altern Complement Med, 2004. 10(6): p. 967-9.

[3]. Dicpinigaitis PV, et, al. Effect of guaifenesin on cough reflex sensitivity. Chest. 2003 Dec;124(6):2178-81.

 Chemical & Physical Properties

Molecular Formula C10H9D5O4
Molecular Weight 203.25