2722635-28-9

2722635-28-9 structure

Name: SARS-CoV-2-IN-11
Chemical Name: SARS-CoV-2-IN-11
CAS Number: 2722635-28-9
Molecular Formula: C₂₇H₃₈F₂N₃NaO₈S
Molecular Weight: 625.66
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2022-03-14 09:05:04
Modify Date: 2024-01-05 18:13:46
SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for therapeutic intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].

Name	SARS-CoV-2-IN-11

Description	SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for therapeutic intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	SARS-CoV-2 3C-like proteas[1]
References	[1]. Dampalla CS, et al. Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies. J Med Chem. 2021;64(24):17846-17865.

Molecular Formula	C₂₇H₃₈F₂N₃NaO₈S
Molecular Weight	625.66